Out of a clinical interest in developing new treatments for retinal diseases, he serves either as Principal Investigator or Co-Investigator in the Retina Research Unit at Wills Eye Hospital for many collaborative national and international clinical trials for conditions such as age-related macular degeneration and diabetic retinopathy. Chiang has contributed over 80 papers, articles, scientific abstracts, and textbook chapters on vitreoretinal diseases and serves as an ad hoc reviewer for multiple journals including RETINA, Ophthalmology Retina, American Journal of Ophthalmology, and British Journal of Ophthalmology. He is an editorial board member of the retina/vitreous section of the AAO’s Ophthalmic News and Education (ONE) Network, which is the Academy’s global platform for continuing medical education for over 30,000 ophthalmologists.ĭr. In addition, he is an elected member of the esteemed Retina Society. Chiang is an active member of the American Academy of Ophthalmology (AAO), American Society of Retina Specialists (ASRS), Association for Research in Vision and Ophthalmology, Pennsylvania Academy of Ophthalmology, Montgomery County Medical Society, and the Vit-Buckle Society. He is currently an Associate Professor of Ophthalmology at Sidney Kimmel Medical College of Thomas Jefferson University and is actively involved in the education and training of the next generation of ophthalmologists and retina specialists.īoard-certified by the American Board of Ophthalmology since 2010, Dr. In 2013, he returned to Philadelphia and the Retina Service of Wills Eye Hospital. Chiang was in private practice in the San Francisco Bay Area as a retina surgeon and recognized as a Top Doctor by Oakland Magazine. Prior to joining Mid Atlantic Retina, Dr. He then completed a two-year medical and surgical retina fellowship at Wills Eye Hospital in Philadelphia and was the recipient of the William Tasman, MD Outstanding Fellow Award. At UCLA, his performance was dually recognized with the Stein Resident Awards for Surgical Excellence and Clinical Research. Thereafter, he completed a residency in ophthalmology at the prestigious Stein Eye Institute at the University of California at Los Angeles (UCLA), perennially the #1 eye hospital in the western US. He then completed a transitional internship at Scripps Mercy Hospital in San Diego, the oldest hospital and one of the best in that region. from the New York University School of Medicine with distinction and selection into the Alpha Omega Alpha Medical Honor Society. Allen Chiang graduated Magna Cum Laude from Brown University. ![]() Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy. Kodera N., Noshiro D., Dora S.K., Mori T., Habchi J., Blocquel D., Gruet A., Dosnon M., Salladini E., Bignon C., et al. Theillet F.-X., Kalmar L., Tompa P., Han K.-H., Selenko P., Dunker A.K., Daughdrill G.W., Uversky V.N. idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R. Review on Dynamic Contour Tonometry and Ocular Pulse Amplitude. Willekens K., Rocha R., Van Keer K., Vandewalle E., Pinto L.A., Stalmans I., Marques-Neves C. Classification of Intrinsically Disordered Regions and Proteins. ![]() Van Der Lee R., Buljan M., Lang B., Weatheritt R.J., Daughdrill G.W., Dunker A.K., Fuxreiter M., Gough J., Gsponer J., Jones D.T., et al. Inherited retinal diseases intrinsically disordered proteins missense variants protein structure. These data suggest that protein function may be related to the overall level of disorder and could be used to refine variant interpretation in IRDs. These proteins also exhibit a lower amount of pathogenic missense variants with respect to total missense variants. We show that proteins with an over-representation of missense variation exhibit a high degree of disorder, and proteins with a high amount of disorder tolerate a higher degree of missense variation. Publicly available data on gnomAD and ClinVar was used to analyze the number of pathogenic missense variants. ![]() Metapredict, an accurate, high-performance predictor that reproduces consensus disorder scores, was used to probe the degree of disorder as a function of the amino acid sequence. The main focus of this work was to investigate the degree of disorder in 14 proteins implicated in IRDs and their relationship with the number of pathogenic missense variants. An understanding of IDRs and their association with biological function may help elucidate the pathogenesis of inherited retinal diseases (IRDs). Intrinsically disordered regions (IDRs) are protein regions that are unable to fold into stable tertiary structures, enabling their involvement in key signaling and regulatory functions via dynamic interactions with diverse binding partners.
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