![]() ![]() I pray for those who are suffering from the results of war and violence. I pray that you provide this world with a peace that is only found in you. A Prayer for Peace: Dear God, Our world is torn with war and violence.Provide for their physical needs, as well as their spiritual needs. God, I pray that you will provide for these needs. I pray for those who don’t have a home, or who have recently just lost their home. I pray for those who don’t have enough money for healthcare or medicine. I pray for those who don’t have enough food to feed themselves or their families. God, I pray for those today who are experiencing financial needs. A Prayer for Poverty: Dear God, So many people are suffering from poverty. ![]() God, I pray for a world full of love and compassion. Show them that you are there, and you care for them and that you will make all things right. Provide peace and hope to those who are suffering from injustice. Help this world to know what is wrong and what is right. Help me to know what is wrong and what is right. I pray for justice and redemption in this world. A Prayer for Justice: Dear God, You are a God of justice.Be with those who are suffering and let them know that you are there. Give them the strength to keep fighting too. God, I pray for their families whose heart aches for their loved ones who are suffering. Provide them with the right tools to begin healing. I pray that they are able to get the help they need. I ask that you bring a community around them that is godly, loving, and understanding. I pray they know that they are loved, wanted, and valued. I pray you give them strength to keep fighting. I pray for those battling mental illness. A Prayer for Mental Illness: Dear God, I come to you with a heavy heart.Provide them with love and a sense of hope. Be with their families that are struggling as they watch their loved ones suffer. I ask that you be with them, comfort them, and provide them with peace. If it is your will, I pray that you heal them, Lord. I pray for those suffering from any form of sickness or ailment. I pray for those suffering from heart disease. I pray for those suffering from COVID-19. A Prayer for Physical Illness: Dear God, I pray for the sickness in our world.I pray for divine appointments all across the world today. I pray for the loss that if not by me, something or someone else will intervene in their life and direct them to you. Help me tell others about you and have the words they need to hear. Allow me to be a source of your light to those who need you. God show yourself to those who don’t believe. A Prayer for the Lost: Dear God, I pray for a world that doesn’t know you.But where do you start? Here are a few prayers to help you begin: Chris Rappazini writes in the Today in the Word devotional, “Even though it may take years to see an answer, you can be assured that your prayers are being heard.” God hears your prayers and it is important that you pray. The needs of our world can be overwhelming and often it can be a struggle to knowing what we should do. All around us, we see heartache, despair, and pain. I had so much to accomplish that I had to take time to pray.Our world is broken. God gently and lovingly chided, “My child, you didn’t knock.” I woke up early this morning and paused before entering the day. I wanted to see joy and beauty, but the day toiled on, gray and bleak. Problems just tumbled about me, and heavier came each task. ![]() I had so much to accomplish that I didn’t have time to pray. I got up early one morning and rushed right into the day. He seated him at his right hand in the heavens, far above every ruler and authority, power and dominion, and every title given, not only in this age but also in the one to come. He exercised this power in Christ by raising Him from the dead. In Jesus’ name, we pray, Amen!Įphesians 1:19 -21 And what is the immeasurable greatness of his power toward us who believe, according to the mighty working of his strength. Thank you, Lord, that we are now seated with you, in Heavenly places, far above all the powers of darkness, and the evil workings of the enemy. There is no fear of the enemy or his devices. Our eyes are fixed on Jesus, the author, and finisher of our faith. We declare that we can walk boldly through this life.
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We want to build up an understanding of the unique sequence and how it has been used to apply it as best we can to our work. In this tutorial, we will look at some examples of how the golden ratio has been used within the genre of art. Once we have the process figured out, we then can play around with how we use it in our work to set up an aesthetically balanced composition. The golden ratio can be a little tricky to understand so you will want to have your full engagement within this tutorial, at least for the first half. Once we have all our necessary materials, we will want to place ourselves within an environment whereby it will help us to focus on the tutorial at hand. Good paper (200 g/m – 250 g/m recommended).All the materials can be found through the different links below: We will also want to make sure that we have an eraser on hand as well as a sharpener for any silly mistakes and to keep our pencils sharp for fine lines. What we will need is a ruler, a pencil, a ballpoint pen, and a compass. We don’t need many materials for this foundational approach to learning the Fibonacci ratio. Learning how to use the golden ratio starts with understanding the basics. There are also various ways to create a Fibonacci sequence and, in this tutorial, we will be looking at the most helpful way to use this sequence in its most basic format. Beneath the complicated versions of both understanding and using this ratio, we will find in this tutorial that it is quite a simple algorithm and quite helpful for aesthetic composition within an artwork. In this tutorial, we will be introduced to the golden ratio, seeing how this particular equation has influenced some artworks and how we can use this sequence in our work. 5.2 Can You Apply the Golden Ratio to Various Subject Matter?Īn Easy Guide to Using the Golden Ratio in Art.5.1 Does the Golden Ratio Create Perfect Balance within Artwork?.3.3 Seeking Out the Golden Ratio in Nature.3 Tips on How to Use the Golden Ratio in Art.2.2.5 Highlighting the Squares and Rectangles.2.2.4 Going Over the Spiral with Ballpoint Pen.2.2.2 Understanding the Sequence in Geometry.2.2.1 Understanding the Sequence in Numbers. ![]() 1 An Easy Guide to Using the Golden Ratio in Art. As the captain of the Big Mom Pirates, Big Mom is known for her insatiable hunger and unpredictable behavior, often driven by her obsession with sweets and her ruthless pursuit of power.īig Mom possesses the Soru Soru no Mi Devil Fruit, granting her the ability to manipulate souls, including extracting them to create powerful homies that serve her. She is one of the Four Emperors, the most powerful and influential pirates in the New World. He is the former president of the infamous crime syndicate Baroque Works and a former member of the Shichibukai, a group of powerful pirates recognized by the World Government.Ĭharlotte Linlin in One Piece (Image via Toei Animation)Ĭharlotte Linlin, commonly referred to as “Big Mom,” is a fearsome and powerful antagonist in the One Piece world. ![]() His electrifying abilities and cunning personality create intense conflicts, making him a memorable antagonist in the One Piece universe.Ħ) Sir Crocodile Sir Crocodile in One Piece (Image via Toei Animation) His character is also closely tied to the unique setting of Skypiea, exploring the themes of faith, religion, and the consequences of unchecked power. Eneru serves as a major antagonist during the Skypiea arc, where he poses a formidable challenge to the Straw Hat Pirates and other characters.Įneru’s god-complex and misuse of his Devil Fruit powers make him a compelling villain in the series. He initially presents himself as a god-like figure, displaying arrogance and ruthlessness in his pursuit of power. Hody’s character is also intertwined with the history and struggles of the fishmen race, adding depth and complexity to his role as a villain in the series.ĩ) Rob Lucci Rob Lucci in One Piece (Image via Toei Animation)Įneru, also known as God of Skypiea, possesses the powerful Logia-type Goro Goro no Mi Devil Fruit, granting him control over electricity. His actions and beliefs raise important themes of racism and the consequences of hatred in the One Piece world. Hody serves as a major antagonist during the Fishman Island arc, where he poses a significant threat to the Straw Hat Pirates and the inhabitants of Fishman Island. He possesses immense strength, speed, and agility due to his fishman physiology, making him a formidable opponent in battle. Hody seeks revenge and aims to overthrow the government to establish fishmen supremacy. He is a radical and extremist fishman who harbors deep-seated hatred towards humans for their mistreatment of fishmen. Hody Jones is the captain of the New Fishman Pirates in One Piece. One Piece: Top 10 antagonists including Doflamingo and Akainu, ranked 10) Hody Jones Hody Jones One Piece (Image via Toei Animation) ![]() ![]() So, the list has been updated with some of the most powerful individuals in the story.Disclaimer: This article is subjective and reflects the writer’s opinion. It goes without saying that they all fall into the category of the strongest characters in One Piece. Due to this reason, it is almost impossible to beat them in combat. These characters have worked on their abilities for a long time and have nearly perfected them. Most of them are much stronger than any of the previous characters that viewers have seen in action. Updated on July 28, 2023, by Suzail Ahmad: As One Piece moves into its final saga, more and more big-name characters are finally coming forward to show what they are truly capable of. With that in mind, here are the strongest characters in One Piece. They are extremely strong, and many of them have the ability to wipe out islands on their own. These characters manage to stand out from the rest due to their personalities, and powers. RELATED: One Piece: Things You Might Not Know About Devil Fruits Aside from its incredible world-building and storyline, One Piece also boasts of having some very impressive characters. ![]() It started serializing in the Weekly Shonen Jump in 1997, and since then it has become a must-read for any manga fan. One Piece is among the most popular shonen series of all time. Garp, and The Five Elders possess immense strength and are formidable opponents in combat. Figarland Garling, The Seraphim, and The Admirals are also incredibly powerful characters in the series. Boa Hancock, Marco, and Mihawk are among the strongest characters in One Piece due to their incredible abilities and skills. ![]() The company is headquartered in Massachusetts, with the large majority of retail locations in the Northeast, and there is already an order of store closures throughout the state. ![]() This timeline could mean that many stores could be closed within just a few weeks. The goal for the company is to get as many stores emptied, with all goods sold, by the end of August. Shoppers can expect to see liquidation sales at their local Christmas Tree Shops starting as soon as July 7. We continue to believe that given its storied history and strong customer loyalty, Christmas Tree Shops has tremendous potential, and we remain committed to the long-term success of the business. “By increasing our financial flexibility, we will be able to focus on continuing to delight our loyal customers with a wide selection of unique goods at affordable prices. “This is strictly a financial restructuring. “After careful consideration, we determined that availing ourselves of the Chapter 11 process was the best way to address our burdensome liabilities,” said Marc Salkovitz, chairman of Christmas Tree Shops, in the official bankruptcy filing. The company filed for Chapter 11 bankruptcy back in May, and will now be forced to liquidate its inventory in the coming weeks if it doesn't get an investor fast.Īccording to the company, the decision to file for bankruptcy was strictly a financial one, and executives had faith in their efforts to move forward and regain strength. ![]() The discount retailer announced it will liquidate all of its 72 brick-and-mortar retail stores after defaulting on its $45 million bankruptcy loan. Photo (c) d3sign - Getty ImagesFollowing in the most recent footsteps of Bed Bath & Beyond and David’s Bridal, Christmas Tree Shops is officially on the chopping block. Jean-Pierre did not say whether the administration would seek to remove Malpass, as that would require the approval of other World Bank members. Februat 11:30 AM 1 min read White House press secretary Karine Jean-Pierre is slated to speak with reporters Tuesday afternoon during a press conference. “There must be accountability for death.”Īsked about the criticism surrounding World Bank President David Malpass’s remarks earlier this week regarding climate change, Jean-Pierre said the Biden administration disagrees with Malpass and “expects the World Bank to be a global leader” on climate.Īt an event sponsored by The New York Times, Malpass wouldn’t answer directly when asked whether the burning of fossil fuels has contributed to global warming. Iran must end its use of violence against women for exercising their fundamental freedoms,” Jean-Pierre said. “Women in Iran should have the right to wear what they want free from violence or harassment. Similar rallies have been held during past periods of widespread protests. The government claimed the demonstrations of support were spontaneous. ![]() Thousands attended a rally in the capital, Tehran, where they waved Iranian flags, and similar demonstrations were held in other cities. Jean-Pierre also commented on the ongoing anti-government protests and unrest in Iran over the death of a young woman who was being held by the morality police. White House press secretary Karine Jean-Pierre called the elections a “sham” and “a flagrant violation of international law and an affront to the principles of sovereignty and territorial integrity that underpin the international system.”Īnd she underscored that “the United States will never recognize this territory as anything other than part of Ukraine because it belongs to the people of Ukraine.” ![]() Kyiv and the West condemned the Kremlin-orchestrated referendums as a rigged election whose result was preordained by Moscow. allies and partners, in response to Russia’s referendums seeking to take over parts of Ukraine. The White House said Friday it is prepared to impose additional “swift and severe economic costs on Russia,” along with U.S. ![]() ![]() ![]() Itunes is Apples music store used to man. Add support for Windows 10 64-bit for N Series Pentium and Celeron processors with HD Graphics. Songs from the Apple Music catalog cannot be burned to a CD. iTunes 64-bit latest version: Managing your media with iTunes 64-bit. Hp Windows 10 Bluetooth Driver free download. Given limitations in the iTunes App Store, we cannot offer a demo of the iOS version at. iTunes-compatible CD or DVD recorder to create audio CDs, MP3 CDs, or backup CDs or DVDs.Internet connection to use Apple Music, the iTunes Store, and iTunes Extras.Screen resolution of 1024x768 or greater 1280x800 or greater is required to play an iTunes LP or iTunes Extras.To play 1080p HD video, a 2.4GHz Intel Core 2 Duo or faster processor, 2GB of RAM, and an Intel GMA X4500HD, ATI Radeon HD 2400, or NVIDIA GeForce 8300 GS or better is required Download Latest Version for Windows iTunes Portable 1/3 When Windows first launched, it came with only one basic program, the very basic iWork compatible version of iTunes.To play 720p HD video, an iTunes LP, or iTunes Extras, a 2.0GHz Intel Core 2 Duo or faster processor, 1GB of RAM, and an Intel GMA X3000, ATI Radeon X1300, or NVIDIA GeForce 6150 or better is required.To play standard-definition video from the iTunes Store, an Intel Pentium D or faster processor, 512MB of RAM, and a DirectX 9.0–compatible video card is required.PC with a 1GHz Intel or AMD processor with support for SSE2 and 512MB of RAM How to Download iTunes on Windows Go to iTuness website, and to the download links. The generic Intel driver provides users the latest and greatest feature enhancements and bug fixes that OEMs may not have customized yet to address platform-specific needs. ![]() Popular Bible Topics What does the Bible say about. Bear-witness Definition Meanings Synonyms Sentences Definition Source Verb Filter verb To deliver a testimony, especially as witness. If something bears witness to a fact, it proves that it is true: 2. Biblical Pronunciation: mahr-too-REH-oh bear witness (to something) definition: 1.Modern International Phonetic Alphabet: mɑr.tjuˈre̞.ow to serve as evidence that something is true or real: Not everyones sobriety can bear witness to the effectiveness of rehab, but in her case it most certainly.Biblical International Phonetic Alphabet: mɑr.tyˈrɛ.o to speak or write about what you have seen, especially as evidence that something is true.To utter honorable testimony, give a good report. To support or prove a claim or idea by ones (or somethings) physical presence.To be a witness, to bear witness, i.e., to affirm that one has seen or heard or experienced something, or that he knows it because taught by divine revelation or inspiration.Usage: Charge, give (evidence), bear record, have (obtain, of) good (honest) report, be well reported of, testify, give (have) testimony, (be, bear, give, obtain) witnessĭefinition: To be a witness, i.e., testify (literally or figuratively). Information sourced from Strong's Concordance. ![]() Tap or hover on blue, underlined words to see more original scripture and meanings. Also below are examples within Bible verses highlighted in yellow (follow this link to go there). What does the source Greek word μαρτυρέω mean and how is it used in the Bible? Below are the English definition details. Here are charge, give, bear record and related words in the Bible. Strong's Concordance, Greek Dictionary Charge, bear record, be well reported of, bear, give, to be a witness, i.e., testify (literally or figuratively) Greek: μαρτυρέω, martyreō (G3140) The name of Beaver’s elementary school teacher-Miss “Landers”-suggested a person who steers children to land amid the stormy seas of childhood. It was set in the fictional town of Mayfield-that is, a “field” in which the young (those in the springtime of life) are formed morally. ![]() ![]() To criticize Beaver for being “idealized” misses the point, for its purpose was not documentary but didactic.īeaver had many trappings of a morality play. Media and popular culture during the Cold War reinforced the domestic ideal, particularly in light of Communism’s disdain for the “bourgeois family.” While divorce and broken homes were becoming more common-in 1949 one writer could already claim that “family life is becoming a thing to be remembered rather than to be lived”-TV domestic sitcoms attempted to shore up the old values, stressing the importance of family in forming character and virtue. After the tumult of World War II, Americans longed for tranquility and order. Leave It to Beaver was an artistic expression of a particular time in history. Mathers’ idea offers the perfect template for viewing this popular classic. As we celebrate Leave It to Beaver‘s sixtieth anniversary, Mr. The show is often misrepresented as a “sanitized,” “unrealistic,” or “cookie cutter” portrayal of a “perfect nuclear family”-phrases which reveal scorn for the very concepts of family and domesticity.īy contrast, Jerry Mathers, who played the title character and was a college philosophy major, has likened the series to a “medieval morality play” in which Theodore “Beaver” Cleaver repeatedly succumbed to temptation, suffered the consequences, and was guided back on the path of virtue. To many, Leave It to Beaver is merely a phrase conjuring up a host of media-propagated clichés about society in the 1950s-bland, “white-bread,” conformist, and so on. The main reason-apart from its top-notch production values-is that it avoided the topical and ephemeral and drew instead from the wellspring of the moral imagination, creating characters and situations which have become archetypes. Viewed today, Leave It to Beaver remains ever fresh, even as other pop-culture products have faded and dated. Since its premiere sixty years ago, the beloved sitcom Leave It to Beaver (1957-63) has been such an “enduring source of inspiration” for many, unfolding the story of a young boy who learned “first principles” and was guided in “virtue and wisdom” in the midst of his family. Russell Kirk defined the moral imagination as “an enduring source of inspiration that elevates us to first principles as it guides us upwards towards virtue and wisdom and redemption.” It is a quality which informs the great works of art, not excluding the more popular art forms of film and television. “Leave It to Beaver” was very much a medieval morality play, in which the character of the Beaver repeatedly succumbed to temptation, suffered the consequences, and was guided back on the path of virtue. Passenger comfort can be supported by Cabin Air Ionisation, now available with PM2.5 air filtration technology. Wireless charging with signal boosting technology is also available as an optional extra. Android Auto is also available as standard. Smartphone integration is also simple, thanks to Apple CarPlay, while the advanced Bluetooth technology can connect two smartphones simultaneously. In addition, customers have the option of a full-colour Head-Up Display, putting high-resolution driving information directly into the driver's eyeline, removing the need to look away from the road ahead. The high-resolution digital instruments can be configured to show a pair of conventional dials, full-screen 3D navigation guidance or a combination of the two, allowing drivers to customise the view to suit their preference. In combination with the 12.3-inch Interactive Driver Display, New Discovery provides high-definition 3D mapping within the instrumentation, leaving the central touchscreen free to control other applications. Land Rover's SOTA technology allows owners to update as many as 44 individual electronic modules, without the inconvenience of visiting a retailer. Its built-in back-up battery means navigation initialisation takes just seconds, while the logical menus allow the most commonly used functions to be accessed directly from the customisable home screen, to reduce driver distraction.Ĭonnectivity is provided by dual-sim technology, with two LTE modems enabling the system to carry out multiple functions at the same time - such as streaming media and downloading Software-Over-The-Air (SOTA) updates - without compromising performance. With a simplified menu structure and pioneering design, Pivi Pro provides immediate responses - even when starting the vehicle for the first time. A completely redesigned centre console houses its 48% larger 11.4-inch, full HD touchscreen, which provides a fast and intuitive interface. Inside, New Discovery benefits from enhancements designed to highlight the premium position and craftsmanship of its full-size seven-seat layout, with a spacious cabin incorporating Land Rover's cutting edge Pivi Pro infotainment. The new R-Dynamic model brings a more assertive character and purposeful stance with a series of unique design elements, including purposeful Gloss Black and Shadow Atlas exterior accents on the outside and two-tone leather and contrast seat stitching on the inside. Following Land Rover's reductive design philosophy, this panel incorporates the trademark Discovery script, providing a cleaner rear graphic. At the rear, New Land Rover Discovery features new signature LED lights, which are joined across the back of vehicle by a new Gloss Black panel. New signature LED headlights with a daytime running light signature set lower into the units create a more purposeful look, while animated sweeping front and rear indicators provide heightened visual sophistication and the body-colour front fender vent accentuates the premium SUV's familiar broken waistline.Ī revised front bumper on the R-Dynamic features a wider body-coloured graphic and new side vents combine for a more purposeful and dynamic appearance. ![]() ![]() Discovery DNA design cues - including the clamshell bonnet, the stepped roof and the highly visible C-pillar - remain, but New Discovery delivers a bold exterior evolution optimised to project a more confident road presence. ![]() ![]() The distinct character and optimised proportions of New Land Rover Discovery embrace more than three decades of design evolution. This compelling and versatile vehicle has been refined in every detail, enhancing its characterful exterior and hugely versatile interior to ensure the Discovery maintains its position as the most capable and family-friendly full-size SUV in the world." Gerry McGovern, Chief Creative Officer, Jaguar Land Rover, said: "New Discovery is a beautifully proportioned and sophisticated premium SUV. From its updated Terrain Response 2 system and Software-Over-The-Air (SOTA) updates to its new Cabin Air Filtration, New Discovery looks after customers like never before. With Land Rover's new Electrical Vehicle Architecture (EVA 2.0) underpinning a suite of advanced technologies, New Discovery delivers new levels of sophistication, desirability and efficiency while retaining its customary breadth of on- and off-road capability and towing credentials. New Land Rover Discovery combines an exceptional design evolution with a versatile and intelligently packaged interior which embodies the spirit of family adventure that has characterised Land Rover's premium family SUV for more than 30 years.įeaturing the latest generation of powerful and efficient six-cylinder Ingenium petrol and diesel engines, advanced Pivi Pro infotainment and superior comfort and practicality, New Discovery remains one of the most capable, connected and versatile full seven-seat premium SUVs in the world. Out of a clinical interest in developing new treatments for retinal diseases, he serves either as Principal Investigator or Co-Investigator in the Retina Research Unit at Wills Eye Hospital for many collaborative national and international clinical trials for conditions such as age-related macular degeneration and diabetic retinopathy. Chiang has contributed over 80 papers, articles, scientific abstracts, and textbook chapters on vitreoretinal diseases and serves as an ad hoc reviewer for multiple journals including RETINA, Ophthalmology Retina, American Journal of Ophthalmology, and British Journal of Ophthalmology. He is an editorial board member of the retina/vitreous section of the AAO’s Ophthalmic News and Education (ONE) Network, which is the Academy’s global platform for continuing medical education for over 30,000 ophthalmologists.ĭr. In addition, he is an elected member of the esteemed Retina Society. Chiang is an active member of the American Academy of Ophthalmology (AAO), American Society of Retina Specialists (ASRS), Association for Research in Vision and Ophthalmology, Pennsylvania Academy of Ophthalmology, Montgomery County Medical Society, and the Vit-Buckle Society. He is currently an Associate Professor of Ophthalmology at Sidney Kimmel Medical College of Thomas Jefferson University and is actively involved in the education and training of the next generation of ophthalmologists and retina specialists.īoard-certified by the American Board of Ophthalmology since 2010, Dr. In 2013, he returned to Philadelphia and the Retina Service of Wills Eye Hospital. Chiang was in private practice in the San Francisco Bay Area as a retina surgeon and recognized as a Top Doctor by Oakland Magazine. Prior to joining Mid Atlantic Retina, Dr. He then completed a two-year medical and surgical retina fellowship at Wills Eye Hospital in Philadelphia and was the recipient of the William Tasman, MD Outstanding Fellow Award. At UCLA, his performance was dually recognized with the Stein Resident Awards for Surgical Excellence and Clinical Research. Thereafter, he completed a residency in ophthalmology at the prestigious Stein Eye Institute at the University of California at Los Angeles (UCLA), perennially the #1 eye hospital in the western US. He then completed a transitional internship at Scripps Mercy Hospital in San Diego, the oldest hospital and one of the best in that region. from the New York University School of Medicine with distinction and selection into the Alpha Omega Alpha Medical Honor Society. Allen Chiang graduated Magna Cum Laude from Brown University. ![]() Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy. Kodera N., Noshiro D., Dora S.K., Mori T., Habchi J., Blocquel D., Gruet A., Dosnon M., Salladini E., Bignon C., et al. Theillet F.-X., Kalmar L., Tompa P., Han K.-H., Selenko P., Dunker A.K., Daughdrill G.W., Uversky V.N. idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R. Review on Dynamic Contour Tonometry and Ocular Pulse Amplitude. Willekens K., Rocha R., Van Keer K., Vandewalle E., Pinto L.A., Stalmans I., Marques-Neves C. Classification of Intrinsically Disordered Regions and Proteins. ![]() Van Der Lee R., Buljan M., Lang B., Weatheritt R.J., Daughdrill G.W., Dunker A.K., Fuxreiter M., Gough J., Gsponer J., Jones D.T., et al. Inherited retinal diseases intrinsically disordered proteins missense variants protein structure. These data suggest that protein function may be related to the overall level of disorder and could be used to refine variant interpretation in IRDs. These proteins also exhibit a lower amount of pathogenic missense variants with respect to total missense variants. We show that proteins with an over-representation of missense variation exhibit a high degree of disorder, and proteins with a high amount of disorder tolerate a higher degree of missense variation. Publicly available data on gnomAD and ClinVar was used to analyze the number of pathogenic missense variants. ![]() Metapredict, an accurate, high-performance predictor that reproduces consensus disorder scores, was used to probe the degree of disorder as a function of the amino acid sequence. The main focus of this work was to investigate the degree of disorder in 14 proteins implicated in IRDs and their relationship with the number of pathogenic missense variants. An understanding of IDRs and their association with biological function may help elucidate the pathogenesis of inherited retinal diseases (IRDs). Intrinsically disordered regions (IDRs) are protein regions that are unable to fold into stable tertiary structures, enabling their involvement in key signaling and regulatory functions via dynamic interactions with diverse binding partners. |
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